The performance of the detection system is seriously affected by the non-uniformity characteristics of infrared seeker imaging.A non-uniformity correction algorithm based on weighted anisotropic infrared seeker is proposed for the non-uniformity correction proposition of infrared seeker.Firstly,the response model of infrared imaging system is briefly described, and the connection between the non-uniformity and the image histogram is analyzed,furthermore, the local weighted anisotropic histogram is introduced, forming a highly performance infrared seeker non-uniformity correction algorithm.The experimental results show that compared with other algorithms, the proposed method has obvious advantages both in terms of actual visual effect and objective quality evaluation, as well as the processing speed.